All projects
Life Sciences
Protein Folding Under Cellular Crowding
Simulating how macromolecular crowding reshapes folding landscapes, reconciling in-vitro kinetics with the dense reality of the living cell.
Objectives
- →Parameterize crowding effects in coarse-grained models
- →Validate against single-molecule FRET data
- →Identify crowding-sensitive folding intermediates
Methodology
Massively parallel molecular dynamics with implicit-crowder potentials, cross-validated against published single-molecule fluorescence trajectories.